In vitro effects of alcesefoliside and mauritianin, isolated from Astragalus monspessulanus subsp. monspessulanus, on the contractility of a. basilaris

Abstract

Flavonoids are one of the most popular antioxidants in plants. Their varied pharmacological activities are important for these compounds in order to add and to complement conventional therapy. Alcesefoliside and mauritianin are rare flavonol triglycosides, isolated from the overground part of A. monspessulanus subsp. monspessulanus. The aim of the study was to examine the in vitro effects of the isolated flavonoids on the contractility of a. basilaris. Administered alone, at concentration 10 µM, alcesefoliside and mauritianin did not influence the vascular tone of segment of a. basilaris. The combination of both compounds, at 10 µM, revealed an increased response of the vascular tone of a. basilaris. These effects of the flavonoids suggest their possible beneficial effect as further candidates in the complex therapy of neurodegenerative disease.