Study of laxative and hepatoprotective activity of extracts obtained from Prunus domestica fruits

Abstract

The experimental work focused on the study of the pharmacological properties of extracts obtained from the Prunus domestica fruits to create a prospective laxative drug with moderate hepatoprotective properties. Prunus domestica fruit extracts have been shown to have a pronounced laxative and moderate hepatoprotective effect. Extract containing fibers at a dose of 200 mg/kg was selected as the most active extract for laxative and hepatoprotective activity among all extracts from the Prunus domestica fruits. It was conventionally named “Prunophyte”. Studies of the specific pharmacological action of “Prunophyte” extract in a model of comorbid functional constipation on the background of combined alcoholic liver disease in rats showed that “Prunophyte” at a dose of 200 mg/kg had positive dynamics in the treatment of constipation on the background of subacute liver disease. In some cases it exceeded the effects of combination therapy with drugs “Silibor” at a dose of 25 mg/kg and “Senadexin” at a dose of 14 mg/kg. “Prunophyte” extract, in contrast to “Senodexin”, did not cause signs of diarrhea in animals, which may be a beneficial feature of this drug in subsequent clinical use. This drug has shown that it can be a promising alternative to a one-time complex treatment with herbal laxatives and hepatoprotectors, which will avoid polypragmatism in the treatment of comorbid conditions in gastroenterology associated with functional constipation and liver dysfunction.