Synovial fluid-derived extracellular vesicles – potential biomarkers of osteoarthritis

Abstract

Osteoarthritis (OA) is a degenerative disease of the musculoskeletal system affecting millions of people around the world. Therefore, research focusing on the correct diagnostics and effective treatment of OA represents a major society-wide challenge. Extracellular vesicles (EVs) as extracellular products of cells containing nucleic acids, proteins and lipids provide intercellular communication and affect the biological activity of cells. This work describes the pathogenesis of OA and the current nomenclature, composition and potential function of EVs associated with this degenerative disease. Investigation of EVs function in OA will help to elucidate the pathogenesis and investigate other new potential biomarkers of this disease.