Accelerated effect on Mitsunobu reaction via bis-N-tert-butoxycarbonylation protection of 2-amino-6-chloropurine and its application in a novel synthesis of penciclovir-Reference-Cited by-同舟云学术

Accelerated effect on Mitsunobu reaction via bis-N-tert-butoxycarbonylation protection of 2-amino-6-chloropurine and its application in a novel synthesis of penciclovir

Published:2013-10 Issue:10 Volume:14 Page:760-766
ISSN:1673-565X
Container-title:Journal of Zhejiang University SCIENCE A
language:en
Short-container-title:J. Zhejiang Univ. Sci. A

Author:

Dai Li-yan,Shi Qiu-long,Zhang Jing,Wang Xiao-zhong,Chen Ying-qi

Publisher

Zhejiang University Press

Subject

General Engineering

Link

http://link.springer.com/content/pdf/10.1631/jzus.A1300238.pdf

Reference30 articles.

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2. Brand, B., Reese, C.B., Song, Q., Visintin, C., 1999.Convenient syntheses of 9-[4-hydroxy-3-(hydroxymethyl)butyl] guanine (penciclovir) and 9-[4-acetoxy-3-(acetoxymethyl) butyl]-2-amino-9H-purine (famciclovir). Tetrahedron, 55(16):5239–5252. [doi:10.1016/S0040-4020(99)00169-6]

3. De Clercq, E., 1991.Broad-spectrum anti-DNA virus and antiretrovirus activity of phosphonylmethoxyalkylpurines and pyrimidines. Biochemical Pharmacology, 42(5):963–972. [doi:10.1016/0006-2952(91)90276-B]

4. Dey, S., Garner, P., 2000.Synthesis of tert-butoxycarbonyl (Boc)-protected purines. The Journal of Organic Chemistry, 65(22):7697–7699. [doi:10.1021/jo000983i]

5. Geen, G.R., Grinter, T.J., Kincey, P.M., Jarvest, R.L., 1990.The effect of the C-6 substituent on the regioselectivity of N-alkylation of 2-aminopurines. Tetrahedron, 46(19): 6903–6914. [doi:10.1016/S0040-4020(01)87878-9]

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