TROMBOPHILIA AS THE MAIN LINK OF PATHOGENESIS OF COMPLICATIONS IN OBSTETRICS AND GYNECOLOGY

Abstract

The analysis of gemostasiologikal researches on hidden got and genetic forms of trombophilia at women with the burdened anamnesis of syndrome of loss of a fetus. For certain established (p<0,05), that got thrombophilia, conditioned by the AFS at patients with FLS average - 28,6 % cases. The genetic mutation FVLeiden more frequent took place at patients with late abortions (14,3 %), the mutation of prothrombin gene G20210A met for certain rarer in all groups of reproduction losses - 4,8 %. The most widespread appeared the mutation МTHFR C677T - (45,2 %). Factor of potential action of the AFA is genetic thrombophilia: AFS and MTHFR C677T at FLS in 17,4 %, AFS and FV Leiden at FLS at 9,6 %. Patogenetically grounded hidden got end genetic thrombophilia, syndrome of loss of fetus, thromboprophylaxis at these obstetric complications of LMWH - by сleхanе, begun with a fertile cycle and on the stage of invasion of throphoblasta, in absolute most cases (92 – 96 %) considerably improves the end of pregnancy.