Affiliation:
1. Mayo Clinic and Mayo Foundation Rochester, Minnesota 55901
Abstract
In dogs anesthetized with α-chloralose, passive alterations in splanchnic blood flow over a range of flows between 10 ml/kg min
-1
and 50 ml/kg min
-1
produced by a blood flow pump or by a change in perfusion pressure were associated with changes in splanchnic blood volume of 0.19 ± 0.1 (SD) ml/kg and 0.43 ± 0.15 ml/kg, respectively, for a change in flow of 1 ml/kg min
-1
. Mechanical increase in splanchnic outflow resistance raised portal venous pressure from a control mean of 6.9 ± 4.1 mm Hg to 15.4 ± 3.5 mm Hg and increased splanchnic blood volume by 8.1 ± 2.2 ml/kg. Of the total change in splanchnic blood volume during an 18-second supramaximal stimulation of the thoracic splanchnic nerves, an estimated 65% was released "passively." The magnitude of this passive release was related linearly to splanchnic blood flow. During increased resistance to splanchnic outflow, the passive release was absolutely and relatively reduced, but the volume of blood actively released by constriction of capacitance elements was absolutely and relatively increased. During hemorrhage (7.2 ml/kg body weight), an average of 4.7 ± 0.6 ml/kg of blood (21% of the calculated splanchnic blood volume) was mobilized, and arterial blood pressure decreased an average of 5%. Repetition of the bleeding after bilateral splanchnicectomy passively mobilized 3.25 ± 0.9 ml/kg of blood (68% of the innervated value), but arterial blood pressure declined by an average of 20%.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
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