Author:
Bevan R D,Purdy R E,Su C,Bevan J A
Abstract
The possibility of changes in the adrenergic innervation of blood vessels in experimental hypertension was investigated by measuring arterial norepinephrine content, neuronal uptake of norepinephrine, and the neurogenic contractile response in rabbits made hypertensive by partial constriction of the abdominal aorta proximal to the kidneys. Two to 3 weeks after surgery, norepinephrine content was increased in the arteries above the ligature, where arterial blood pressure was increased, but not in the arteries below the ligature, where arterial blood pressure was normal, in the heart, or in the veins. Neuronal norepinephrine uptake per unit length of vessel and the neurogenic contractile response increased with the rise in arterial blood pressure. The neurogenic contractile response can be taken as an indication of an increase in transmitter release. The results taken together suggest an increase in the function and possibly the amount of the adrenergic neuroneal terminal in hypertension. Since the distributions of the changes in the adrenergic innervation and the increases in smooth muscle cell proliferation in hypertension are similar, these two processes may be interrelated.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
Reference33 articles.
1. com.atypon.pdfplus.internal.model.plusxml.impl.AuthorGroup@1b0f7d8d
: In Perspectives in Neuropharmacology edited by SH Snyder. New York Oxford University Press 1972
2. com.atypon.pdfplus.internal.model.plusxml.impl.AuthorGroup@15c8809c
: Alteration in tyrosine hydroxylase and monoamine oxidase in blood vessels. Nature [New Biol] 231:252-253 1971
3. Altered norepinephrine synthesis of splanchnic vessels in neurogenic hypertension
4. com.atypon.pdfplus.internal.model.plusxml.impl.AuthorGroup@54f58aa7
: High Blood Pressure. Churchill London 1968
Cited by
43 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献