Effect of the Endecapeptide Eledoisin on the Coronary Blood Flow: Comparison with Nitroglycerin, Bradykinin and Epinephrine in the Dog

Author:

BERGAMASCHI MARIO1,GLÄSSER ALFREDO H.1

Affiliation:

1. Laboratori di Ricerca Farmitalia S.p.A. Via dei Gracchi, 35, Milano, Italia

Abstract

The effects on coronary blood flow of the endecapeptide Eledoisin have been studied in the anesthetized dog. Eledoisin increases coronary blood flow without increasing myocardial contractility and heart rate. Nitroglycerin and the polypeptide bradykinin increase coronary blood flow in the same way, but are markedly less active than Eledoisin. l -Epinephrine increases coronary blood flow, but at the same time produces a stimulating action on the myocardium.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Reference11 articles.

1. Structure and pharmacological actions of eledoisin, the active endecapeptide of the posterior salivary glands of eledone

2. Synthesis of eledoisin

3. The action of Eledoisin on the systemic arterial blood pressure of some experimental animals;ERSPAMER V.;Brit. J. Pharmacol.,1963

4. Pharmacological actions of Eledoisin on extravascular smooth muscle;ERSPAMER V.;Brit. J. Pharmacol.,1962

5. tiber durehblutnngmessungen an organen in situ, insbesondere mit der Thermost.rumulir;REIN H.;Ergeb. Pbysiol.,1944

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