Effect of Variations of Plasma Sodium Concentration on the Adrenal Response to Angiotensin II

Author:

BLAIR-WEST JOHN R.1,COGHLAN JOHN P.1,DENTON DEREK A.1,GODING JAMES R.1,WINTOUR MARELYN1,WRIGHT R. DOUGLAS

Affiliation:

1. Howard Florey Laboratories of Experimental Physiology, University of Melbourne, Parkville, N.2., Australia

Abstract

The secretion rate of aldosterone was increased by infusion of valine-5-angiotensin II into the adrenal arterial blood supply of sheep. The dimensions of the increase in aldosterone output were inversely related to the control plasma concentration. This high aldosterone secretion was reduced substantially by concurrent adrenal infusion of concentrated NaCl solution which increased plasma sodium concentration by approximately 10 meq/liter. The reduction of aldosterone secretion occurred within 20 minutes. Angiotensin II infusion did not increase the secretion rates of cortisol or corticosterone. The significance of the finding that environmental sodium concentration has different effects on the aldosterone-stimulating action and the pressor action of angiotensin II is discussed.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Reference32 articles.

1. Adrenocortical function in essential hypertension. In Essential Hypertension, ed. by K. D. Bock and P. T. Cottier, Berlin;GENEST J.;Springer-Verlag,1960

2. Hypotensive Agents and Pressor Substances

3. RELATION OF RENIN, ANGIOTENSIN II, AND EXPERIMENTAL RENAL HYPERTENSION TO ALDOSTERONE SECRETION*

4. Stimulation of aldosterone secretion by angiotensin n;MULROW P. J.;Yale J. Biol. Med.,1961

5. The control of aldosterone secretion;BLAIR-WEST J. R.;Recent Progr. Hormone Res.,1963

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3