Affiliation:
1. Hemodynamic Laboratory, Cardiovascular Research Laboratories, Department of Internal Medicine, State University of Iowa, College of Medicine Iowa City, Iowa
Abstract
The cardiovascular effects of intravenous guanethidine were measured in animals treated with reserpine. The action of intraarterial guanethidine was studied also in perfused forelegs of dogs. The following conclusions were reached:
1. There was no significant increase in cardiac output, heart rate, or systemic arterial pressure following intravenous guanethidine in treated animals; only sustained vasodilatation was observed.
2. The vasodilatation was caused by a local action of the drug on vascular smooth muscle. The dilatation became more pronounced following depletion of catecholamines with reserpine and repeated administration of guanethidine.
3. The dilatation did not appear to be mediated through the release of catecholamines, histamine, or acetylcholine. It may have resulted, at least in part, from stimulation of
beta
adrenergic receptors or other "dilator receptors" which are blocked by dichloroisoproterenol.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
Cited by
24 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献