Ouabain Effects on Cardiac Contraction, Action Potential, and Cellular Potassium-Reference-Cited by-同舟云学术

Ouabain Effects on Cardiac Contraction, Action Potential, and Cellular Potassium

Published:1965-07 Issue:1 Volume:17 Page:46-56
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circulation Research

Author:

MüLLER PAUL¹

Affiliation:

1. Department of Physiology, University of Berne, Berne, Switzerland

Abstract

Transmembrane potential, isometric tension, and K 42 content of sheep or calf myocardial bundles were recorded simultaneously during periods up to 30 hours. Ouabain at low concentrations (1.5 x 10 -8 M/L) decreased intracellular K to a new steady level which was reached after several hours. Its value depended on drug concentration. The effect was reversible. There was a striking temporal parallelism between the potassium loss and the inotropic effect which was suggestive of a close relationship between the two phenomena. Action potentials during these experiments did not change in a consistent way.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.RES.17.1.46

Reference67 articles.

1. WILBRANDT W.: New aspects of cardiac glycosides: Introduction. Proc. First Pharmacol. Meeting vol. 3 p. 3 New York Pergamon Press Inc. 1963.

2. KLAUS W.: Neuere Aspekte iiber den Wirkungsmechanismus der Herzglykoside. Ztschr. nat. med. Grundlg. forsch. 2: 43 1964.

3. BING R. J.: The effect of digitalis on cardiac metabolism. Proc. First Pharmacol. Meeting vol. 3 p. 75 New York Pergamon Press Inc. 1963.

4. The high energy phosphate content of cardiac muscle under various experimental conditions which alter contractile strength;FUHCHCOTT R.;J. Pharmacol. Exptl. Therap.,1958

5. LEE K. S.: Relation of cations to the inotropic and metabolic actions of cardiac glycosides. Proc. First Pharmacol. Meeting vol. 3 p. 185 New York Pergamon Press Inc. 1963.

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