Magnesium Deficiency in the Cebus Monkey

Author:

VITALE JOSEPH J.1,VELEZ HERNAN1,GUZMAN CARLOS1,CORREA PELAYO1

Affiliation:

1. Departments of Nutrition, Pathology and Experimental Surgery, Universidad del Valle Cali, Colombia, S. A., and Department of Nutrition Harvard School of Public Health, Boston, Massachusetts.

Abstract

Purified diets containing cholesterol and deficient or adequate in magnesium were fed to young growing Cebus (fatuella) monkeys. Diet-induced magnesium deficiency resulted in weight loss, hyperirritability, and in several monkeys, convulsions. In addition to the expected hypomagnesemia, deficient animals also had decreased serum potassium levels. However, after several weeks on diet, the electrocardiogram of deficient animals showed significant changes consisting primarily of S-T segment depression and peaking of the T wave; changes usually seen in hyperkalemic states. Prior to sacrificing the animals, the tolerance to K-strophanthidin, a cardiac glycoside, was ascertained in both deficient and control animals. The cardiac glycoside was administered slowly by the intravenous route to anesthetized monkeys and the appearance of four consecutive ventricular premature contractions in the electrocardiogram was taken as the end-point. Deficient animals required approximately one-half the dose administered to control monkeys to develop extrasystoles. The histopathology consisted of marked vascular sudanophilic deposits and dense fibrous connective tissue plaques in the ascending and descending aorta of deficient monkeys. Control animals showed little, if any, vascular sudanophilia. The serum cholesterol concentration increased significantly in the deficient group while the rise seen in control monkeys lacked statistical significance.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Reference37 articles.

1. Studies on the interrelationships between dietary magnesium and calcium in atherogenesis and renal lesions. Am. X din;VLTALE J.;Nutr.,1959

2. The Effect of Low Temperature and Dietary Calcium upon Magnesium Requirement

3. Magnesium requirement and its relation to other dietary constituents;O'DELL B. L.;Federation Proc.,1960

4. Magnesium Metabolism

5. Plasma magnesium in health and disease

Cited by 60 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3