Chronotropic Effects of Norepinephrine and Tyramine: A System Response Analysis-Reference-Cited by-同舟云学术

Chronotropic Effects of Norepinephrine and Tyramine: A System Response Analysis

Published:1964-08 Issue:2 Volume:15 Page:112-123
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circulation Research

Author:

BATTERSBY EDWARD J.¹,NEWMAN ELLIOT V.¹

Affiliation:

1. Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee

Abstract

An analog simulation of the chronotropic effects of norepinephrine and tyramine in the canine heart-lung preparation is presented. The temporal aspects of those responses are described in quantitative terms. Reserpine produced deprivation suprasensitivity to norepinephrine may be considered as a corollary of the system response nonlinearity to that drug. Discrepancies between tyramine rate responses and the relatively small amounts of norepinephrine released are resolved by the assumption that the receptor space for norepinephrine has a capacitative function and is not in free dilutional equilibrium with the perfusing blood. This mechanism would allow for a unitary explanation of tyramine action based upon competition with norepinephrine for available storage sites.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.RES.15.2.112

Reference14 articles.

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2. Some observations on the effects of tyramine. In Adrenergic Mechanisms. Boston, Little;NASMYTH P. A.;Brown and Company,1960

3. The effect of norepinephrine infusions upon some responses of reserpine treated spinal cats to tyramine;SMITH E. R.;J. Pharmacol. Exptl. Therap.,1963

4. Release of Norepinephrine from the Heart by Vasoactive Amines

5. The Mode of Action of Tyramine

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4. ADRENERGIC DRUGS;The Nervous System;1967