Anemia-induced Changes in Cardiac Output in Dogs Treated with Dichloroisoproterenol-Reference-Cited by-同舟云学术

Anemia-induced Changes in Cardiac Output in Dogs Treated with Dichloroisoproterenol

Published:1962-03 Issue:3 Volume:10 Page:354-358
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circulation Research

Author:

GOWDEY CHARLES W.¹

Affiliation:

1. Department of Pharmacology, Faculty of Medicine, University of Western Ontario London, Ontario, Canada

Abstract

The cardiac output of anesthetized dogs was markedly elevated by the production of severe acute anemia by exchanging dextran for blood. Dichloroisoproterenol, in a dose which completely blocked the positive chronotropic effect of epinephrine and several reflexes, usually had minimal effects on the cardiac output. The cardiac responses to acute anemia were not different in the DCI-treated and the control groups. It is concluded that the effect of acute anemia on cardiac output is probably not mediated by the action of adrenergic substances on the heart.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.RES.10.3.354

Reference4 articles.

1. Sympathoadrenal System and Response of Heart to Acute Exchange Anemia

2. Adrenergic blockade of the mammalian heart by a dichloro analogue of isoproterenol;MORAN N. C;J. Pharmacol. & Exper. Therap.,1958

3. NAHAS G. G. MATHER G. W. WARGO J. D. M. AND ADAMS W. L.: Influence of acute hypoxia on the pulmonary circulation of sympathoctomized and adrenaleetomized dogs. Air Force School of Aviation Medicine Project No. 21-1204-0001 Beport No. 5 1955.

4. Regulation of circulation: VIII. Relative importance of nervous, endocrine and vascular regeneration in the response of the cardiac output to anemia;HARRISON T. B.;Am. J. Physiol.,1927

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