Affiliation:
1. Department of Physiology, University of Minnesota School of Medicine Minneapolis, Minn Department of Biochemistry, Western Reserve University School of Medicine Cleveland, Ohio
Abstract
Experimental cardiac failure was reinvestigated in the completely isolated mammalian heart using a simplified system in which only the left ventricle performs work and exhibits volume changes. An effort was made to assess the importance of such experimental artefacts as acapnia, altered or depleted substrate, and controlled (constant) diastolic volume. None of these factors appeared to play a determining role in the mechanism of experimental failure, which was characterized by a decline in mechanical efficiency, with little or no impairment of total energy liberation.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
Cited by
44 articles.
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