Influence of Ouabain on Contractile Force, Resting Tension, Ca 45 Entry and Tissue Ca Content in Rat Atria-Reference-Cited by-同舟云学术

Influence of Ouabain on Contractile Force, Resting Tension, Ca 45 Entry and Tissue Ca Content in Rat Atria

Published:1963-06 Issue:6 Volume:12 Page:620-622
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circulation Research

Author:

GERSMEYER GUDRUN¹,HOLLAND WILLIAM C.¹

Affiliation:

1. University of Mississippi School of Medicine, Jackson, Mississippi

Abstract

As was the case with guinea pig atria, ouabain induced a small but significant increment in Ca 45 uptake and a drop of tissue Ca content in rat atria during the positive inotropic effect. In ouabain contractures, the uptake rate increased 87% to 170% and there was little increase in tissue Ca. Concentrations of the glycosides required to produce a positive inotropic effect and contracture in rat atria were 100- to 200-fold greater than those required in guinea pig atria.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.RES.12.6.620

Reference10 articles.

1. Effect of potassium lack and ouabain on calcium uptake in frog's heart;THOMAS U.;Federation Proc.,1958

2. Effect of ouabain on Ca45 and C1M exchange in isolated rabbit atria;HOLLAND W. C;Am. J. Physiol.,1959

3. Influence of ouabain on an exchangeable calcium fraction, contractile force and resting tension of guinea-pig atria. .;LULLMANN H.;T. Pharmacol. Exp. Therap.,1962

4. Wirkung von Frequenz, Natriumentzug und Strophanthin auf Kontraktionskraft und Alkaligehalt des Herzrrraskels. Naunyn-Schmiedebergs Arch. Exp. P.ithol;REITER M.;Pharmakol.,1956

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1. Mobilization of a Vesamicol-Insensitive Pool of Acetylcholine from a Sympathetic Ganglion by Ouabain;Journal of Neurochemistry;1993-07

2. Sodium dependence of carnitine transport in isolated perfused adult rat hearts;American Journal of Physiology-Heart and Circulatory Physiology;1983-02-01

3. Extracellular calcium concentration and calcium blocking agents on the action of ouabain on isolated rat atrium;Pharmacological Research Communications;1982-01

4. Influence of ouabain on Ca exchangeability in resting atria of guinea-pig;European Journal of Pharmacology;1981-08

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