1. From the Department of Cardiovascular Medicine, the Cleveland Clinic Foundation, Cleveland, Ohio (M.K.C., D.O.M., D.S., O.W., A.K., P.J.T., M.J.N., A.N., D.R.V.W.) and the College of Pharmacy and the Dorothy M. Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio (J.A.B., C.A.C.).