1. From School of Physiology & Pharmacology, University of Bristol, United Kingdom (E.O.A., M.T.J.v.d.B., E.B., C.M.W., I.H., A.W.P.; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, The Netherlands (N.J.A.M., J.M.E.M.C., J.W.M.H.); and Welsh Blood Service and Arthur Bloom Haemophilia Centre, School of Medicine, Cardiff University, United Kingdom (P.W.C.).