1. From the Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (E.M., J.B.S., M.A.M.); Department of Epidemiology, Harvard School of Public Health, Boston, MA (E.M., M.A.M.); Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada (M.M.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (G.H.T.); and InfraReDx, Burlington, MA (J.E.M.).