MicroRNA-122–Mediated Liver Detargeting Enhances the Tissue Specificity of Cardiac Genome Editing

Author:

Yang Luzi12ORCID,Liu Zhanzhao12,Chen Gonglie12ORCID,Chen Zhan12ORCID,Guo Congting12ORCID,Ji Xiangwen23ORCID,Cui Qinghua42ORCID,Sun Yueshen56ORCID,Hu Xiaomin5ORCID,Zheng Yanjiang7,Li Yifei7ORCID,Gao Fei8ORCID,Chen Liang9ORCID,Zhou Pingzhu10ORCID,Pu William T.11ORCID,Guo Yuxuan1212ORCID

Affiliation:

1. School of Basic Medical Sciences and Institute of Cardiovascular Sciences (L.Y., Z.L., G.C., Z.C., C.G., Y.G.), Peking University Health Science Center, Beijing, China.

2. State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China (L.Y., Z.L., G.C., Z.C., C.G., X.J., Q.C., Y.G.).

3. Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China (X.J.).

4. School of Basic Medical Sciences Department of Biomedical Informatics, Center for Noncoding RNA Medicine (Q.C.), Peking University Health Science Center, Beijing, China.

5. Department of Cardiology, Peking Union Medical College Hospital (Y.S., X.H.)., Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

6. Department of Medical Research Center, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China (X.H.).

7. Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu (Y.Z., Y.L.).

8. Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, China (F.G.).

9. State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases (L.C.), Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

10. School of Medicine, Shanghai University, China (P.Z.).

11. Boston Children’s Hospital and Harvard Stem Cell Institute, MA (W.T.P.).

12. Beijing Key Laboratory of Cardiovascular Receptors Research, China (Y.G.).

Publisher

Ovid Technologies (Wolters Kluwer Health)

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