Adventures in Cardiovascular Research

Author:

Braunwald Eugene1

Affiliation:

1. From the Thrombolysis in Myocardial Infarction Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical School, Boston, Mass.

Abstract

This article, derived from an invited Distinguished Scientist lecture presented at the American Heart Association Scientific Sessions in 2007, reviews 4 themes (adventures) in clinical cardiovascular research carried out over a period of 58 years. It begins with the author’s introduction to cardiovascular hemodynamics during a medical school elective in 1951. The 4 adventures include valvular heart disease, hypertrophic cardiomyopathy, heart failure (HF), and myocardial ischemia. In each of these adventures, the author describes briefly what was known when he entered each field, followed by the author’s contribution to the field (the adventure), and ends with comments about the current status of the field. Of particular interest are the changes in the technologies used in clinical cardiovascular research over the past half century, commencing with pressure tracings in left heart chambers with the use of needle puncture in the operating room to genetic technologies designed to understand differences between drugs that inhibit platelet activation. The article ends with some general comments on conducting research and the rewards that can come with this activity.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Limitation of Infarct Size and the Open Artery Hypothesis;Circulation;2016-09-20

2. Eugene Braunwald, MD;The Journal of Thoracic and Cardiovascular Surgery;2013-10

3. Cardiovascular Pharmacologic Therapies Under Investigation;Cardiology in Review;2012-05

4. Mechanisms of variability of left ventricular outflow tract gradient in hypertrophic cardiomyopathy;International Journal of Cardiology;2010-11

5. Eugene Braunwald;Circulation Research;2010-06-25

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