Progress Toward Cardiac Xenotransplantation-Reference-Cited by-同舟云学术

Progress Toward Cardiac Xenotransplantation

Published:2020-10-06 Issue:14 Volume:142 Page:1389-1398
ISSN:0009-7322
Container-title:Circulation
language:en
Short-container-title:Circulation

Author:

Pierson Richard N¹²^ORCID,Fishman Jay A.²,Lewis Gregory D.³^ORCID,D’Alessandro David A.¹,Connolly Margaret R.¹²,Burdorf Lars¹²,Madsen Joren C.¹²,Azimzadeh Agnes M.¹²

Affiliation:

1. Division of Cardiac Surgery, Department of Surgery (R.N.P., D.A.D., M.R.C., L.B., J.C.M., A.M.A.), Massachusetts General Hospital and Harvard University, Boston.

2. Center for Transplantation Sciences (R.N.P., J.A.F., M.R.C., L.B., J.C.M., A.M.A.), Massachusetts General Hospital and Harvard University, Boston.

3. Division of Cardiology, Department of Medicine (G.D.L.), Massachusetts General Hospital and Harvard University, Boston.

Abstract

Consistent survival of life-supporting pig heart xenograft recipients beyond 90 days was recently reported using genetically modified pigs and a clinically applicable drug treatment regimen. If this remarkable achievement proves reproducible, published benchmarks for clinical translation of cardiac xenografts appear to be within reach. Key mechanistic insights are summarized here that informed recent pig design and therapeutic choices, which together appear likely to enable early clinical translation.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

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