Insulin-Like Growth Factor-1 Receptor Deficiency in Macrophages Accelerates Atherosclerosis and Induces an Unstable Plaque Phenotype in Apolipoprotein E

Insulin-Like Growth Factor-1 Receptor Deficiency in Macrophages Accelerates Atherosclerosis and Induces an Unstable Plaque Phenotype in Apolipoprotein E–Deficient Mice

Published:2016-06-07 Issue:23 Volume:133 Page:2263-2278
ISSN:0009-7322
Container-title:Circulation
language:en
Short-container-title:Circulation

Author:

Higashi Yusuke¹,Sukhanov Sergiy¹,Shai Shaw-Yung¹,Danchuk Svitlana¹,Tang Richard¹,Snarski Patricia¹,Li Zhaohui¹,Lobelle-Rich Patricia¹,Wang Meifang¹,Wang Derek¹,Yu Hong¹,Korthuis Ronald¹,Delafontaine Patrice¹

Affiliation:

1. From Departments of Medicine (Y.H., S.S., S.D., P.S., Z.L., P.D.) and Medical Pharmacology and Physiology (Y.H., S.S., M.W., D.W., H.Y., R.K.), University of Missouri School of Medicine, Columbia; and Department of Medicine, Tulane University School of Medicine, New Orleans, LA (S.-Y.S., R.T., P.L.-R.).

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference98 articles.

1. Low Serum Insulin-Like Growth Factor I Is Associated With Increased Risk of Ischemic Heart Disease

2. The Prospective Association of Serum Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-1 Levels with All Cause and Cardiovascular Disease Mortality in Older Adults: The Rancho Bernardo Study

3. Effects of insulin-like growth factor 1 in preventing acute coronary syndromes: The PRIME study

4. Low circulating insulin-like growth factor I increases atherosclerosis in ApoE-deficient mice

5. IGF-1 Reduces Inflammatory Responses, Suppresses Oxidative Stress, and Decreases Atherosclerosis Progression in ApoE-Deficient Mice

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