Association Between Maternal Chronic Conditions and Congenital Heart Defects

Author:

Liu Shiliang1,Joseph K.S.1,Lisonkova Sarka1,Rouleau Jocelyn1,Van den Hof Michiel1,Sauve Reg1,Kramer Michael S.1

Affiliation:

1. From the Health Surveillance and Epidemiology Division, Centre for Chronic Disease Prevention, Public Health Agency of Canada, Ottawa, ON, Canada (S. Liu, J.R.); Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada (S. Liu); Department of Obstetrics and Gynaecology, University of British Columbia and the Children’s and Women’s Hospital of British Columbia, Vancouver, BC, Canada (K.S.J., S. Lisonkova); School of Population and Public Health, University of...

Abstract

Background— This study quantifies the association between maternal medical conditions/illnesses and congenital heart defects (CHDs) among infants. Methods and Results— We carried out a population-based study of all mother-infant pairs (n=2 278 838) in Canada (excluding Quebec) from 2002 to 2010 using data from the Canadian Institute for Health Information. CHDs among infants were classified phenotypically through a hierarchical grouping of International Statistical Classification of Diseases and Related Health Problems, 10th Revision, Canada codes. Maternal conditions such as multifetal pregnancy, diabetes mellitus, hypertension, and congenital heart disease were defined by use of diagnosis codes. The association between maternal conditions and CHDs and its subtypes was modeled using logistic regression with adjustment for maternal age, parity, residence, and other factors. There were 26 488 infants diagnosed with CHDs at birth or at rehospitalization in infancy; the overall CHD prevalence was 116.2 per 10 000 live births, of which the severe CHD rate was 22.3 per 10 000. Risk factors for CHD included maternal age ≥40 years (adjusted odds ratio [aOR], 1.48; 95% confidence interval [CI], 1.39–1.58), multifetal pregnancy (aOR, 4.53; 95% CI, 4.28–4.80), diabetes mellitus (type 1: aOR, 4.65; 95% CI, 4.13–5.24; type 2: aOR, 4.12; 95% CI, 3.69–4.60), hypertension (aOR, 1.81; 95% CI, 1.61–2.03), thyroid disorders (aOR, 1.45; 95% CI, 1.26–1.67), congenital heart disease (aOR, 9.92; 95% CI, 8.36–11.8), systemic connective tissue disorders (aOR, 3.01; 95% CI, 2.23–4.06), and epilepsy and mood disorders (aOR, 1.41; 95% CI, 1.16–1.72). Specific CHD subtypes were associated with different maternal risk factors. Conclusions— Several chronic maternal medical conditions, including diabetes mellitus, hypertension, connective tissue disorders, and congenital heart disease, confer an increased risk of CHD in the offspring.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3