1. From the Department of Pharmacology and Toxicology (A.K., R.J., M.J.L.) and Department of Internal Medicine (R.J.), University of Würzburg, Würzburg, Germany; Department of Pharmacy–Center for Drug Research (X.Z., M.B.), Ludwig Maximilian University of Munich, München, Germany; and Institute of Experimental and Clinical Pharmacology and Toxicology (A.K., N.B., L.H.), University of Freiburg, Freiburg, Germany.