1. From the Institute for Translational Medicine and Therapeutics (S.U.N., X.W., M.P.R., J.T.B., D.J.R.), Cardiovascular Institute (M.P.R., D.J.R.), and Institute for Diabetes Obesity and Metabolism (M.P.R., D.J.R.), University of Pennsylvania School of Medicine, Philadelphia; The Children’s Hospital of Philadelphia, Philadelphia, Pa (J.S.D., G.H.R.); and GlaxoSmithKline, King of Prussia, Pa (M.J., C.H.M.).