Unlocking the Secrets of Mitochondria in the Cardiovascular System-Reference-Cited by-同舟云学术

Unlocking the Secrets of Mitochondria in the Cardiovascular System

Published:2019-10 Issue:14 Volume:140 Page:1205-1216
ISSN:0009-7322
Container-title:Circulation
language:en
Short-container-title:Circulation

Author:

Tian Rong¹,Colucci Wilson S.²,Arany Zoltan³,Bachschmid Markus M.²,Ballinger Scott W.⁴,Boudina Sihem⁵,Bruce James E.⁶,Busija David W.⁷,Dikalov Sergey⁸,Dorn Gerald W.⁹,Galis Zorina S.¹⁰,Gottlieb Roberta A.¹¹,Kelly Daniel P.³,Kitsis Richard N.¹²,Kohr Mark J.¹³,Levy Daniel¹⁰,Lewandowski E. Douglas¹⁴,McClung Joseph M.¹⁵,Mochly-Rosen Daria¹⁶,O’Brien Kevin D.⁶,O’Rourke Brian¹⁷,Park Joon-Young¹⁸,Ping Peipei¹⁹,Sack Michael N.¹⁰,Sheu Shey-Shing²⁰,Shi Yang¹⁰,Shiva Sruti²¹,Wallace Douglas C.²²,Weiss Robert G.¹⁷,Vernon Hilary J.²³,Wong Renee¹⁰,Longacre Lisa Schwartz¹⁰,Shi Scarlet

Affiliation:

1. Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine (R.T.), University of Washington, Seattle.

2. Department of Medicine, Boston University, MA (W.S.C., M.M.B.).

3. Department of Medicine, University of Pennsylvania, Philadelphia (Z.A., D.B.K.).

4. Department of Pathology, University of Alabama at Birmingham (S.W.B.).

5. Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City (S.B.).

6. Department of Genome Sciences (J.E.B.), University of Washington, Seattle.

7. Department of Pharmacology, Tulane University, New Orleans, LA (D.W.B.).

8. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (S.D.).

9. Center for Pharmacogenomics, Department of Internal Medicine, Washington University, St. Louis, MO (G.W.D.).

10. National, Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (Z.S.G., D.L., M.N.S., Y.S., R.W., L.S.L.).

11. Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (R.A.G.).

12. Department of Medicine, Department of Cell Biology, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY (R.N.K.).

13. Departments of Environmental Health and Engineering (M.J.K.), The Johns Hopkins University, Baltimore, MD.

14. Department of Internal Medicine, The Ohio State University, Columbus (E.D.L.).

15. Department of Physiology, East Carolina University, Greenville, NC (J.M.M.).

16. Department of Chemical and Systems Biology, Stanford University, CA (D.M.-R.).

17. Medicine (B.O., R.G.W.), The Johns Hopkins University, Baltimore, MD.

18. Department of Kinesiology, Temple University, Philadelphia, PA (J.-Y.P.).

19. Department of Physiology and Department of Medicine, University of California, Los Angeles (P.P.).

20. Department of Medicine, Thomas Jefferson University, Philadelphia, PA (S.-S.S.).

21. Department of Pharmacology and Chemical Biology and Vascular Medicine Institute, University of Pittsburgh, PA (S.S.).

22. Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia Research Institute, PA (D.C.W.).

23. Genetic Medicine (H.J.V.), The Johns Hopkins University, Baltimore, MD.

Abstract

Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiovascular diseases, and mitochondria research in August 2018. These experts reviewed the current state of science and identified key gaps and opportunities in basic, translational, and clinical research focusing on the potential of mitochondria-based therapeutic strategies in heart failure. The workshop provided short- and long-term recommendations for moving the field toward clinical strategies for the prevention and treatment of heart failure and cardiovascular diseases by using mitochondria-based approaches.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference71 articles.

1. Bioenergetics of the failing heart

2. The Failing Heart — An Engine Out of Fuel

3. Mitochondrial dysfunction in pathophysiology of heart failure

4. Cyclosporine before PCI in Patients with Acute Myocardial Infarction

5. Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients

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