Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling

Author:

Nakano Toshiaki1,Katsuki Shunsuke1,Chen Mingxian1,Decano Julius L.2,Halu Arda23,Lee Lang Ho2,Pestana Diego V. S.1,Kum Angelo S. T.1,Kuromoto Rodrigo K.1,Golden Whitney S.1,Boff Mario S.1,Guimaraes Gabriel C.1,Higashi Hideyuki2,Kauffman Kevin J.4,Maejima Takashi2,Suzuki Takehiro5,Iwata Hiroshi2,Barabási Albert-László36,Aster Jon C.7,Anderson Daniel G.4,Sharma Amitabh23,Singh Sasha A.2,Aikawa Elena12,Aikawa Masanori123

Affiliation:

1. Center for Excellence in Vascular Biology (T.N., S.K., M.C., D.V.S.P., A.S.T.K., R.K.K., W.S.G., M.S.B., G.C.G., E.A., M.A.), Brigham and Women’s Hospital, Harvard Medical School, Boston, MA.

2. Center for Interdisciplinary Cardiovascular Sciences (J.L.D., A.H., L.H.L., H.H., T.M., H.I., A.S., S.A.S., E.A., M.A.), Brigham and Women’s Hospital, Harvard Medical School, Boston, MA.

3. Division of Cardiovascular Medicine, Channing Division of Network Medicine (A.H., A.-L.B., A.S., M.A.), Brigham and Women’s Hospital, Harvard Medical School, Boston, MA.

4. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge (K.J.K., D.G.A.).

5. Division of Medical Science, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan (T.S.).

6. Center for Complex Network Research, Northeastern University, Boston, MA (A.-L.B.).

7. Department of Medicine, and Department of Pathology (J.C.A.), Brigham and Women’s Hospital, Harvard Medical School, Boston, MA.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

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