Affiliation:
1. Section of Pediatric Cardiology Department of Pediatrics Texas Children's HospitalBaylor College of Medicine Houston TX
2. Department of Cardiology Boston Children's HospitalHarvard Medical School Boston MA
3. Cardiovascular Engineering, Inc. Norwood MA
4. Section of Cardiovascular Medicine Department of Medicine Boston University School of Medicine Boston MA
5. Department of Epidemiology Boston University School of Public Health and Boston University Center for Computing and Data Sciences Boston MA
Abstract
Background
Aortic stiffening begins in youth and antedates future hypertension. In adults, excess weight, systemic inflammation, dyslipidemia, insulin resistance, neurohormonal activation, and altered adipokines are implicated in the pathogenesis of increased aortic stiffness. In adolescents, we assessed the relations of comprehensive measures of aortic stiffness with body mass index (BMI) and related but distinct circulating biomarkers.
Methods and Results
A convenience sample of 246 adolescents (mean age, 16±2 years; 45% female, 24% Black, and 43% Hispanic) attending primary care or preventive cardiology clinics at 2 tertiary hospitals was grouped as normal weight (N=98) or excess weight (N=148, defined as BMI ≥age‐ and sex‐referenced 85th percentile). After an overnight fast, participants underwent anthropometry, noninvasive arterial tonometry, and assays for serum lipids, CRP (C‐reactive protein), glucose, insulin, renin, aldosterone, and leptin. We used multivariable linear regression to relate arterial stiffness markers (including carotid‐femoral pulse wave velocity) to BMI
z
score and a biomarker panel. Carotid‐femoral pulse wave velocity was higher in excess weight compared with normal weight group (5.0±0.7 versus 4.6±0.6 m/s;
P
<0.01). After multivariable adjustment, carotid‐femoral pulse wave velocity was associated with BMI
z
score (0.09 [95% CI, 0.01–0.18];
P
=0.04) and with low‐density lipoprotein cholesterol (0.26 [95% CI, 0.03–0.50];
P
=0.03).
Conclusions
Higher BMI and low‐density lipoprotein cholesterol were associated with greater aortic stiffness in adolescents. Maintaining optimal BMI and lipid levels may mitigate aortic stiffness.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献