Affiliation:
1. Department of Neurosurgery Ajou University School of Medicine Suwon Republic of Korea
2. Departments of Biomedical Informatics College of Medicine Konyang University Daejeon Republic of Korea
3. Department of Otorhinolaryngology‐Head and Neck Surgery College of Medicine Konyang University Daejeon Republic of Korea
4. Department of Otorhinolaryngology‐Head and Neck Surgery Chuncheon Sacred Heart HospitalHallym University College of Medicine Chuncheon Republic of Korea
5. Institutes of New Frontier Research Hallym University College of Medicine Chuncheon Republic of Korea
Abstract
Background
Patients with aortic disease (AD) might have a higher prevalence of intracranial aneurysm (IA). The present study evaluated the prevalence of IA in patients with AD and identified potential risk factors of IA using nationwide representative cohort sample data.
Methods and Results
We defined AD as both aortic dissections and aortic aneurysms. This study used a nationwide representative cohort sample from the Korea National Health Insurance Service–National Sample Cohort database from 1.1million patients. Using
χ
2
or Fisher’s exact tests, the prevalence of the IA in patients with AD and potential risk factors for their concurrence were analyzed. The prevalence of IA in patients with AD was 6.8% (155/2285). The adjusted odds ratios (OR) for having concurrent IA in patients with AD was 3.809 (95% CI, 3.191–4.546;
P
<0.01). Patients with AD and hypertension were >19 times more likely to be affected by IA (adjusted OR, 18.679; 95% CI, 16.555–21.076;
P
<0.01). Patients with AD and diabetes mellitus, old age (>60 years), and male sex were >4, 3, and 2 times more likely to be affected by IA, respectively (adjusted OR, 4.291, 3.469, and 1.983, respectively; 95% CI, 3.914–4.704, 3.152–3.878, and 1.779–2.112, respectively). Subgroup analysis with socioeconomic status or disability revealed that the prevalence of IA was significantly higher in all groups.
Conclusions
In the current population‐based study, the prevalence of IA in patients with AD was quadrupled compared with that in the general population. Early IA screening might be considered among patients with AD for appropriate management.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
6 articles.
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