Association of Coronary Wall Shear Stress With Atherosclerotic Plaque Burden, Composition, and Distribution in Patients With Coronary Artery Disease

Author:

Eshtehardi Parham1,McDaniel Michael C.1,Suo Jin2,Dhawan Saurabh S.1,Timmins Lucas H.12,Binongo José Nilo G.3,Golub Lucas J.1,Corban Michel T.1,Finn Aloke V.1,Oshinsk John N.2,Quyyumi Arshed A.1,Giddens Don P.2,Samady Habib1

Affiliation:

1. Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA

2. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA

3. Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA

Abstract

Background Extremes of wall shear stress ( WSS ) have been associated with plaque progression and transformation, which has raised interest in the clinical assessment of WSS . We hypothesized that calculated coronary WSS is predicted only partially by luminal geometry and that WSS is related to plaque composition. Methods and Results Twenty‐seven patients with coronary artery disease underwent virtual histology intravascular ultrasound and Doppler velocity measurement for computational fluid dynamics modeling for WSS calculation in each virtual histology intravascular ultrasound segment (N=3581 segments). We assessed the association of WSS with plaque burden and distribution and with plaque composition. WSS remained relatively constant across the lower 3 quartiles of plaque burden ( P =0.08) but increased in the highest quartile of plaque burden ( P< 0.001). Segments distal to lesions or within bifurcations were more likely to have low WSS ( P< 0.001). However, the majority of segments distal to lesions (80%) and within bifurcations (89%) did not exhibit low WSS . After adjustment for plaque burden, there was a negative association between WSS and percent necrotic core and calcium. For every 10 dynes/cm 2 increase in WSS , percent necrotic core decreased by 17% ( P =0.01), and percent dense calcium decreased by 17% ( P< 0.001). There was no significant association between WSS and percent of fibrous or fibrofatty plaque components ( P = NS ). Conclusions In patients with coronary artery disease: (1) Luminal geometry predicts calculated WSS only partially, which suggests that detailed computational techniques must be used to calculate WSS . (2) Low WSS is associated with plaque necrotic core and calcium, independent of plaque burden, which suggests a link between WSS and coronary plaque phenotype. ( J Am Heart Assoc. 2012;1:e002543 doi: 10.1161/ JAHA .112.002543.)

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3