Affiliation:
1. Center for Primary Health Care Research, Region Skåne/Lund University, Malmö, Sweden
2. Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA
Abstract
Background
Although the heritability of atrial fibrillation/atrial flutter (
AF
/
AF
l) has been determined, the familial risk in multiplex families is unclear. The main aim of this nationwide study was to determine the familial risk of
AF
/
AF
l in multiplex families.
Methods and Results
We examined the familial risk of
AF
/
AF
l in the entire Swedish population. We linked Multigeneration Register data on individuals aged 0 to 76 years with Hospital Discharge Register data for 1987–2008 and Outpatient Register data for 2001–2008 to compare
AF
/
AF
l risk among relatives of all 300 586 individuals with
AF
/
AF
l with that among relatives of unaffected individuals. We used conditional logistic regression to investigate differences in exposure between cases and controls. Parents (odds ratio [
OR
] 1.95 [95% CI 1.89 to 2.00]) and siblings (
OR
=3.08 [3.00 to 3.16]) of cases had higher odds of
AF
/
AF
l than did parents and siblings of controls.
AF
/
AF
l
OR
s were increased in both sexes. For 2% of cases, both parents had
AF
/
AF
l, compared with only 0.7% of controls (
OR
=3.60 [3.30 to 3.92]). Moreover, 3% of cases had ≥2 siblings with
AF
/
AF
l, compared with 1% of controls (
OR
=5.72 [5.28 to 6.19]). In premature cases (diagnosed at age <50 years), the
OR
s were 5.04 (4.36 to 5.82) and 8.51 (6.49 to 11.15) for
AF
/
AF
l in both parents and
AF
/
AF
l in ≥2 siblings, respectively. The overall spouse
OR
was 1.16 (1.13 to 1.19).
Conclusions
Family history of
AF
/
AF
l increases the odds of
AF
/
AF
l in first‐degree relatives. High familial risks were observed in multiplex families.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
35 articles.
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