Effects of Physical Activity and Sedentary Time on the Risk of Heart Failure

Author:

Young Deborah Rohm1,Reynolds Kristi1,Sidell Margo1,Brar Somjot1,Ghai Nirupa R.1,Sternfeld Barbara1,Jacobsen Steven J.1,Slezak Jeffrey M.1,Caan Bette1,Quinn Virginia P.1

Affiliation:

1. From the Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena (D.R.Y., K.R., M.S., N.R.G., S.J.J., J.M.S., V.P.Q.); Department of Cardiology, Kaiser Permanente Southern California, Los Angeles (S.B.); and Department of Research, Kaiser Permanente Northern California, Oakland (B.S., B.C.).

Abstract

Background— Although the benefits of physical activity for risk of coronary heart disease are well established, less is known about its effects on heart failure (HF). The risk of prolonged sedentary behavior on HF is unknown. Methods and Results— The study cohort included 82 695 men aged ≥45 years from the California Men’s Health Study without prevalent HF who were followed up for 10 years. Physical activity, sedentary time, and behavioral covariates were obtained from questionnaires, and clinical covariates were determined from electronic medical records. Incident HF was identified through International Classification of Diseases, Ninth Revision codes recorded in electronic records. During a mean follow-up of 7.8 years (646 989 person-years), 3473 men were diagnosed with HF. Controlling for sedentary time, sociodemographics, hypertension, diabetes mellitus, unfavorable lipid levels, body mass index, smoking, and diet, the hazard ratio (95% confidence interval [CI]) of HF in the lowest physical activity category compared with those in the highest category was 1.52 (95% CI, 1.39–1.68). Those in the medium physical activity category were also at increased risk (hazard ratio, 1.17 [95% CI, 1.06–1.29]). Controlling for the same covariates and physical activity, the hazard ratio (95% CI) of HF in the highest sedentary category compared with the lowest was 1.34 (95% CI, 1.21–1.48). Medium sedentary time also conveyed risk (hazard ratio, 1.13 [95% CI, 1.04–1.24]). Results showed similar trends across white and Hispanic subgroups, body mass index categories, baseline hypertension status, and prevalent coronary heart disease. Conclusions— Both physical activity and sedentary time may be appropriate intervention targets for preventing HF.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

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