Characteristics and Outcomes of COVID-19 in Patients on Left Ventricular Assist Device Support-Reference-Cited by-同舟云学术

Characteristics and Outcomes of COVID-19 in Patients on Left Ventricular Assist Device Support

Published:2021-04 Issue:4 Volume:14 Page:
ISSN:1941-3289
Container-title:Circulation: Heart Failure
language:en
Short-container-title:Circ: Heart Failure

Author:

Birati Edo Y.¹²³^ORCID,Najjar Samer S.⁴^ORCID,Tedford Ryan J.⁵^ORCID,Houston Brian A.⁵^ORCID,Shore Supriya⁶^ORCID,Vorovich Esther⁷^ORCID,Atluri Pavan⁸,Urgo Kimberly¹^ORCID,Molina Maria¹,Chambers Susan¹,Escobar Nicole¹,Hsich Eileen⁹^ORCID,Estep Jerry D.⁹,Alexander Kevin M.¹⁰^ORCID,Teuteberg Jeffrey J.¹⁰,Chaudhry Sunit-Preet¹¹^ORCID,Ravichandran Ashwin¹¹^ORCID,DeVore Adam D.¹²^ORCID,Margulies Kenneth B.¹^ORCID,Hanff Thomas C.¹^ORCID,Zimmer Ross¹^ORCID,Kilic Arman¹³^ORCID,Wald Joyce W.¹,Vidula Himabindu¹⁴^ORCID,Martens John¹⁴^ORCID,Blumberg Emily A.¹⁵^ORCID,Mazurek Jeremy A.¹,Owens Anjali T.¹,Goldberg Lee R.¹,Alvarez-Garcia Jesus¹⁶,Mancini Donna M.¹⁶^ORCID,Moss Noah¹⁶^ORCID,Genuardi Michael V.¹^ORCID

Affiliation:

1. Cardiovascular Division, Department of Medicine (E.Y.B., K.U., M.M., S.C., N.E., K.B.M., T.C.H., R.Z., J.W.W., J.A.M., A.T.O., L.R.G., M.V.G.), University of Pennsylvania, Philadelphia.

2. Perelman School of Medicine and Cardiovascular Outcomes, Quality, and Evaluative Research Center (E.Y.B.), University of Pennsylvania, Philadelphia.

3. Cardiovascular Division, Poriya Medical Center, Bar-Ilan University, Israel. (E.Y.B.)

4. MedStar Washington Hospital Center, Washington, DC (S.S.N.).

5. Medical University of South Carolina, Charleston, SC (R.J.T., B.A.H.).

6. Cardiovascular Division, University of Michigan, Ann Arbor (S.S.).

7. Division of Cardiology, Northwestern University, Chicago, IL (E.V.).

8. Department of Cardiothoracic Surgery (P.A.), University of Pennsylvania, Philadelphia.

9. Heart and Vascular Institute at the Cleveland Clinic and Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, OH (E.H., J.D.E.).

10. Division of Cardiovascular Medicine and the Stanford Cardiovascular Institute, Stanford University School of Medicine, CA (K.M.A., J.J.T.).

11. St Vincent Medical Group, St Vincent Heart Center, Indianapolis, IN (S.-P.C., A.R.).

12. Duke Clinical Research Institute and Department of Medicine, Duke University School of Medicine, Durham, NC (A.D.D.).

13. Division of Cardiac Surgery, University of Pittsburgh Medical Center, PA (A.K.).

14. Division of Cardiology, University of Rochester School of Medicine and Dentistry, NY (H.V., J.M.).

15. Division of Infectious Diseases (E.A.B.), University of Pennsylvania, Philadelphia.

16. Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, NY (J.A.-G., D.M.M., N.M.).

Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic continues to afflict millions of people worldwide. Patients with end-stage heart failure and left ventricular assist devices (LVADs) may be at risk for severe COVID-19 given a high prevalence of complex comorbidities and functional impaired immunity. The objective of this study is to describe the clinical characteristics and outcomes of COVID-19 in patients with end-stage heart failure and durable LVADs. Methods: The Trans-CoV-VAD registry is a multi-center registry of LVAD and cardiac transplant patients in the United States with confirmed COVID-19. Patient characteristics, exposure history, presentation, laboratory data, course, and clinical outcomes were collected by participating institutions and reviewed by a central data repository. This report represents the participation of the first 9 centers to report LVAD data into the registry. Results: A total of 40 patients were included in this cohort. The median age was 56 years (interquartile range, 46–68), 14 (35%) were women, and 21 (52%) were Black. Among the most common presenting symptoms were cough (41%), fever, and fatigue (both 38%). A total of 18% were asymptomatic at diagnosis. Only 43% of the patients reported either subjective or measured fever during the entire course of illness. Over half (60%) required hospitalization, and 8 patients (20%) died, often after lengthy hospitalizations. Conclusions: We present the largest case series of LVAD patients with COVID-19 to date. Understanding these characteristics is essential in an effort to improve the outcome of this complex patient population.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

Reference23 articles.

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5. Left Ventricular Assist Devices in the Management of Heart Failure

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