1. From the Department of Cardiovascular Medicine (T. Kato, S.N., Y.I., T. Kawashima, J.O., Y.T., Y.I., T. Kita, T. Kimura, T.S.), Graduate School of Medicine, and Department of Systems Science (M.N., T.M.), Graduate School of Informatics, Kyoto University, Kyoto, and Institute for Advanced Bioscience (T.S.), Keio University, Yamagata, Japan.