Affiliation:
1. From the Department of Medicine (C.A.), Manchester Royal Infirmary, Manchester, and The Physiological Laboratory (S.W.), The University of Liverpool, Liverpool, UK.
Abstract
Abstract
—Ca
2+
and H
+
ions can profoundly alter vascular tone. In many physiological and pathological processes, changes in the concentration of both ions occur. Thus, to understand the processes and mechanisms that modify force, it is necessary to understand what changes occur in these ions and, importantly, how they interact with each other. In this minireview, we highlight the quantitatively important mechanisms involved in the contractile responses of vascular tissues to pH change and discuss the cellular and molecular reasons underlying these responses.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
Cited by
71 articles.
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