Distribution of a Persistent Sodium Current Across the Ventricular Wall in Guinea Pigs-Reference-Cited by-同舟云学术

Distribution of a Persistent Sodium Current Across the Ventricular Wall in Guinea Pigs

Published:2000-11-10 Issue:10 Volume:87 Page:910-914
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circulation Research

Author:

Sakmann Bernhard F. A. S.¹,Spindler Anthony J.¹,Bryant Simon M.¹,Linz Klaus W.¹,Noble Denis¹

Affiliation:

1. From the University Laboratory of Physiology (B.F.A.S.S., A.J.S., K.W.L., D.N.) and Department of Cardiovascular Medicine, John Radcliffe Hospital (S.M.B.), Oxford, UK.

Abstract

Abstract —A tetrodotoxin-sensitive persistent sodium current, I pNa , was found in guinea pig ventricular myocytes by whole-cell patch clamping. This current was characterized in cells derived from the basal left ventricular subendocardium, midmyocardium, and subepicardium. Midmyocardial cells show a statistically significant ( P <0.05) smaller I pNa than subendocardial and subepicardial myocytes. There was no significant difference in I pNa current density between subepicardial and subendocardial cells. Computer modeling studies support a role of this current in the dispersion of action potential duration across the ventricular wall.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.RES.87.10.910

Reference23 articles.

1. Gintant GA Datyner NB Cohen IS. Slow inactivation of tetrodotoxin-sensitive current in canine cardiac Purkinje fibres. Biophys J .

2. Slow inactivation of the sodium current in rabbit cardiac Purkinje fibres

3. Slow currents through single sodium channels of the adult rat heart.

4. A persistent sodium current in rat ventricular myocytes.

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