1. From the Department of Physiology (L.L.C., J.-H.L., J.Y., A.D., E.P.-R.) and the Cardiovascular Institute (L.L.C., E.P.-R.), Loyola University Medical Center, Maywood, Ill; the Department of Physiology (J.S., Y.Z.), University of Kentucky, Lexington, Ky; the Department of Paediatrics (J.B., M.P.W., M.R.), The Rayne Institute, University College London Medical School, London, UK; and the MRC Human Biochemical Genetics Unit (M.F.), The Galton Laboratory, London, UK.