Affiliation:
1. Department of Physiology, Latter-day Saints Hospital and University of Utah, Salt Lake City, Utah
Abstract
Heart rate was controlled by direct stimulation of the right ventricle of a dog previously subjected to complete A-V block in order to study the effect of this variable on cardiac output. Measurements of cardiac output were made at various heart rates in unanesthetized dogs, both at rest and walking on a treadmill. Except at the extremes, cardiac output was independent of heart rate at rest and during mild exercise. This finding emphasizes the fact that cardiac output may be regulated to provide required flow through changes in stroke volume alone, even though adjustment of heart rate is the usual means for obtaining this end.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
Reference5 articles.
1. Constancy of stroke volume in ventricular responses to exertion;EUSHMER B. F .;Am. J. Physiol.,1959
2. Relative contribution of changes in heart rate and stroke volume to the increase in cardiac output in dogs during exercise;SHEPHERD J. T.;Physiologist,1959
3. Production of heart block in dogs under direct vision;TAUFIC M.;Surg. Forum,1955
4. Quantitation of Beat-to-Beat Changes in Stroke Volume From the Aortic Pulse Contour in Man
5. Use of an analog computer for analysis of control mechanisms in the circulation;WARNER H. E.;Proceedings of Institute of Eadio Engineers,1959
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