Atherosclerosis in Rats Induced by Repeated Breedings, ACTH and Unilateral Nephrectomy-Reference-Cited by-同舟云学术

Atherosclerosis in Rats Induced by Repeated Breedings, ACTH and Unilateral Nephrectomy

Published:1960-01 Issue:1 Volume:8 Page:278-286
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circulation Research

Author:

WEXLER BERNARD C.¹,BROWN THOMAS E.¹,MILLER BENJAMIN F.¹

Affiliation:

1. May Institute for Medical Research of the Cincinnati Jewish Hospital; and the Departments of Pathology and Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio

Abstract

Repeatedly-bred rats of both sexes develop subintimal accumulations of acid mucopolysaccharides and fibroblastic proliferation followed by distortion and destruction of elastic lamellae. Fibrosis, endothelial hyperplasia, lipid deposition, calcification and atheromata are also observed. Changes in the elastic tissue occur independently, and later than the alterations of the ground substance and the fibroblasts. Calcification is found in more advanced lesions, showing an affinity for areas rich in mucopolysaccharides. Exogenous ACTH and unilateral nephrectomy augment early atherosclerotic changes associated with multiple breedings.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.RES.8.1.278

Reference27 articles.

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3. Acid mucopolysaccharides in degenerative disease of connective tissue, with special reference to serous inflammation;ALTSIIULER C. H.;Am. J. Path.,1951

4. Pathogenesis of experimental arteriosclerosis in pyridoxine deficiency;RINEHART J. F.;Arch Path.,1951

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