Effect of Liver Damage on Experimental Renal Hypertension in the Rat

Author:

LOYKE H. F.1,PLUCINSKY J. J.1,CRAWFORD T. L.1

Affiliation:

1. Research Department, St. Vincent Charity Hospital, Cleveland, Ohio

Abstract

Renal hypertension was produced in 26 test rats and fell to normal levels when they received CCl 4 . Our data indicate that this is due to liver damage and not to general inanition. These changes are reversible, since cessation of CCl 4 injections led to blood pressure rise. Morphologically, only a moderate degree of fatty metamorphosis is necessary to cause the blood pressure to fall from hypertensive levels to normotension. The biochemical change involved variable changes in albumin and globulin.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Reference14 articles.

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2. Les Hepatites. Paris;LOEPER M.;Masson et Cie,1937

3. THE INCIDENCE OF HYPERTENSION IN PORTAL CIRRHOSIS: A STUDY OF 80 NECROPSIED CASES OF PORTAL CIRRHOSIS

4. Jaundice and blood pressure;MEAKINS J. C.;Med. Clin. N. America,1932

5. RAASCHOU F . : Blood pressure and heart weight in chronic hepatitis. Nord. med. 42: 1791 1949.

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