1. From the Departments of Medicine II (S.F., H. Matsubara, K.M., Y.M., Y.T., H. Masaki, Y.U., Y.K., A.N., O.I., E.T., T.I.) and Ophthalmology (N.J., N.O.), Kansai Medical University, Osaka; Pharmacological Laboratory (Y.N.), Taiho Pharmaceutical Co. Ltd., Tokushima; and Department of Biochemistry (S.H.), School of Allied Health Science, Osaka University Faculty of Medicine, Osaka, Japan.