Affiliation:
1. Department of Physiology, Harvard School of Public Health, Boston, Mass
Abstract
Pressure-volume relationships and myocardial oxygen consumption (V
·
O
2
) were obtnined in an isolated heart during ventricular fibrillation, potassium-induced arrest, and isovolumetric contractions. The heart was found to be less distensible in fibrillation than in diastole or arrest. The V
·
O
2
increased from 4.6 to 14.6 cc./100 Gm. LV/min. as the fibrillating ventricle was distended. During arrest the V
·
O
2
remained constant despite ventricular distention. When the fibrillating ventricle was distended beyond a critical point coronary flow was compromised and the V
·
O
2
decreased. Beyond and only beyond this point could the V
·
O
2
be increased by the greater coronary flow induced by a higher perfusion pressure.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
Cited by
104 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献