1. From the Institute of Experimental and Clinical Pharmacology and Toxicology (A.D., S.W., U.S., P.D.), Medical University of Lübeck, Lübeck, Germany; Biochemistry Department (J.M.S.), University of Colorado Medical School, Denver, Colo; and Global Product Planning and Development (N.I.), Fujisawa Pharmaceutical Co., Yodogawa-Ku, Osaka, Japan.