Short Communication: The Neuropeptide Substance P Mediates Adventitial Mast Cell Activation and Induces Intraplaque Hemorrhage in Advanced Atherosclerosis

Author:

Bot Ilze1,de Jager Saskia C.A.1,Bot Martine1,van Heiningen Sandra H.1,de Groot Paul1,Veldhuizen Roel W.1,van Berkel Theo J.C.1,von der Thüsen Jan H.1,Biessen Erik A.L.1

Affiliation:

1. From the Division of Biopharmaceutics (I.B., S.C.A.d.J., M.B., S.H.v.H., T.J.C.v.B., E.A.L.B.), Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University; Departments of Cardiology (P.d.G.) and Pathology (R.W.V.), Medisch Centrum Haaglanden, The Hague; Department of Pathology (J.H.v.d.T.), Academic Medical Center, Amsterdam; and Experimental Vascular Pathology Group (E.A.L.B.), Department of Pathology, University of Maastricht, The Netherlands.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

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3. Role of the Mast Cell–Neuron Tandem in Cardiac Function Regulation in Cardiovascular Pathologies;Journal of Evolutionary Biochemistry and Physiology;2024-03

4. Cellular and Molecular Mechanisms of Mast Cells in Atherosclerotic Plaque Progression and Destabilization;Clinical Reviews in Allergy & Immunology;2024-01-30

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