1. From the Division of Biopharmaceutics (I.B., S.C.A.d.J., M.B., S.H.v.H., T.J.C.v.B., E.A.L.B.), Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University; Departments of Cardiology (P.d.G.) and Pathology (R.W.V.), Medisch Centrum Haaglanden, The Hague; Department of Pathology (J.H.v.d.T.), Academic Medical Center, Amsterdam; and Experimental Vascular Pathology Group (E.A.L.B.), Department of Pathology, University of Maastricht, The Netherlands.