1. From the School of Medical Sciences and Bosch Institute (Y.K.J., J.L., B.H.L., D.L., D.G.A.), University of Sydney, Sydney, Australia; Baker IDI Heart and Diabetes Institute (E.A.W.), Melbourne, Australia; School of Biomedicine (M.L.), Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK; Department of Physiology and Pharmacology (M.B.C.), University of Bristol, Bristol, UK.