1. From the Departments of Anesthesia and Medicine and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.F.-M., B.O., D.C., A.M., S.S., D.D., J.K., E.S., N.I.-I., F.S., G.I., T.H., A.L., J.K., P.A., M.R.); and the Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, Italy (S.O.).