1. From the Departments of Medicine (Cardiology) (J.K., L.Z., K.P., J.-H.W., D.A.Z., L.B., S.M.D., S.T.E., R.J.L., N.J.F.), Biochemistry (R.J.L.), Cell Biology (N.J.F.), and the Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, NC. Present address for K.P.: Jefferson University Center for Translational Medicine, Philadelphia, Pa.