1. From the Departments of Anesthesia and Medicine and Division of Cardiovascular Medicine, Brigham and Women's Hospital (P.G., Y.B., D.D., J.F.-M., H.Z., S.S., T.H., P.A., J.K., M.R., A.L.); and Cardiovascular Institute (F.d.M.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Montefiore Medical Center (C.F., D.A.D., R.E.M.), Albert Einstein College of Medicine, New York; and Department of Biotechnology and Bioscience (S.O.), University of Milano-Bicocca, Milan, Italy.