COVID-19 and Cardiovascular Disease

Author:

Chung Mina K.123ORCID,Zidar David A.34,Bristow Michael R.5ORCID,Cameron Scott J.123ORCID,Chan Timothy123,Harding Clifford V.3ORCID,Kwon Deborah H.123,Singh Tamanna123,Tilton John C.3,Tsai Emily J.6,Tucker Nathan R.78ORCID,Barnard John12ORCID,Loscalzo Joseph9ORCID

Affiliation:

1. Cleveland Clinic (M.K.C., S.J.C., T.C., D.H.K., T.S., J.B.), OH.

2. Cleveland Clinic Lerner College of Medicine (M.K.C., S.J.C., T.C., D.H.K., T.S., J.B.), OH.

3. Case Western Reserve University School of Medicine (M.K.C., D.A.Z., S.J.C., T.C., C.V.H., D.H.K., T.S., J.C.T.), OH.

4. Louis Stokes Cleveland Veterans Affairs Medical Center, OH (D.A.Z.).

5. University of Colorado Anschutz Medical Center, Aurora (M.R.B.).

6. Columbia University Vagelos College of Physicians and Surgeons, New York (E.J.T.).

7. Masonic Medical Research Institute, Utica, NY (N.R.T.).

8. Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Boston, MA (N.R.T.).

9. Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (J.L.).

Abstract

A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential consequences on the cardiovascular health of millions of people who survive infection worldwide. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, can infect the heart, vascular tissues, and circulating cells through ACE2 (angiotensin-converting enzyme 2), the host cell receptor for the viral spike protein. Acute cardiac injury is a common extrapulmonary manifestation of COVID-19 with potential chronic consequences. This update provides a review of the clinical manifestations of cardiovascular involvement, potential direct SARS-CoV-2 and indirect immune response mechanisms impacting the cardiovascular system, and implications for the management of patients after recovery from acute COVID-19 infection.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

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